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   Table of Contents - Current issue
July-December 2022
Volume 1 | Issue 2
Page Nos. 45-92

Online since Tuesday, September 26, 2023

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Assessment of hypoglycemic effect of homoeopathic drug Insulinum in the patients suffering from type 2 diabetes mellitus: A prospective nonrandomized single-blind clinical trial p. 45
Nivedita Pattanaik, Chaturbhuja Nayak, Xinix Xavier
Introduction: Diabetes mellitus (DM) is described as a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbance of carbohydrate, fat, and protein metabolism resulting from defect in insulin secretion, insulin action, or both. The increasing prevalence and incidence of DM in developing countries are due to the trend of urbanization and lifestyle changes, including a “Western-style” diet. However, the exact mechanism is not clearly understood to date. DM is classified broadly into type 1 DM (insulin-dependent DM), which is 5%–10% of all cases, and type 2 DM (noninsulin-dependent DM), which accounts for 90%–95% of all cases of DM. Globally, as of 2013, an estimated 382 million people have type 2 DM making up about 90% of the cases. This is equal to 8.3% of the adult population. In 2015, there were 5 million deaths from DM, that is, in every 6 s one person dies from it. It is the eighth leading cause of death. The evidence given by American Universities Group Diabetes Program suggests that conventional treatment can contribute to early death. Alternatively, homoeopathic intervention being safe and cost-effective, it was proposed to explore the role of an organ remedy Insulinum in reducing the blood sugar level and improving the quality of life of such patients suffering from type 2 DM. Materials and Methods: It was a prospective, observational, nonrandomized, noncontrolled, single-blind clinical trial. Results: Of 155 patients, 50 patients (36 males and 14 females) with type 2 DM were enrolled in the study. After a follow-up period of 12 months of treatment, the analysis was done. In the study population, the fasting blood sugar (FBS) baseline mean value was 7.5 mmol/L, which was reduced to 6.7 mmol/L, and the postprandial blood sugar (PPBS) baseline mean value was 11.6 mmol/L, which was reduced to 10.5 mmol/L at the end of treatment. The mean haemoglobin (HbA1C)% value was 8.066% at the baseline, whereas at the end of the treatment, it was reduced to 6.656% and the baseline DM mean score (based on cardinal symptoms of DM) was 8.8, which was reduced to 2.02 at the end of the treatment. Conclusion: The hypoglycemic effect of homoeopathic organ remedy Insulinum during the treatment of type 2 DM was confirmed through this study. The medicine was also helped to improve the quality of life of the patients.
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Scientific insights in the preparation and characterization of a traditionally prepared Vanga Bhasma by three methods p. 51
Manjiri Anil Ranade
Introduction: Jarana and Marana processes are mentioned for making Bhasma in metals having low melting point such as Naga, Vanga, and Yashada. No research work was done stating the physiochemical and elemental changes happening after Jarana, as well as Ariloha (Haratala) marita and Parda marita Vanga Bhasma (VB). The present study deals with the preparation of VB by three different methods and physiochemical analysis at each stage of preparation. Materials and Methods: Three types of test drugs Vanaspati jarita VB (VB-A), Vanaspati Jarita, Haralal Marita VB (VB-B), and Parada, Haratal Marita VB (VB-C), were prepared as per the guidelines of pharmaceutics of Ayurveda. Discussion and Results: The organoleptic characters of the raw, shodhit, Jarita Vanga, and VB were then studied, followed by the elemental assay, and the changes in the elemental constituents were compared and studied with the elemental constituents of Asuddha Vanga, Shodhit Vanga, and VB (Haratal and Parada marita). Rekhapurnata was found after Jaran stage, and it increased after Maran process. VB-B and -C passed all the classical organoleptic parameters. Energy-dispersive X-ray spectroscopy research shows Sn and O as main ingredients, and Hg was present in VB-C. All of the Bhasma samples included Fe, Pt, and Si. Conclusion: Despite being smooth to the touch and devoid of heavy metals, Jarita vanga does not satisfy all the standards of classical Bhasma parikshas. For a patient’s safe consumption, VB made using the Putapaka method may be recommended. VB prepared using any of these techniques could produce nanoparticle-sized particles.
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Barriers to performance in state level cricketers: A cross sectional study p. 56
Radhika Chintamani, Akanksha Sharma
Background: Studies have demonstrated various barriers present for players and athletes such as physical injuries, mental health, inter-personal relationship, physical appearance, gender barrier, lack of societal acceptance, non-disclosure of religious beliefs, low socio-economic status, and so on. Cricket is the most popular game in India. In a country of 1.4 billion, almost millions of people love to play cricket and support the players. But, very few studies entail various barriers faced by the cricketers. Hence, the aim of the current study is to identify the most prevalent barrier for the participation restriction in state level cricketers in present times. Materials and Methods: A total of 150 male cricketers were recruited on the basis of inclusion and exclusion criteria. Outcome measures such as exercise benefit and barrier scale, SF-36 questionnaire, perceived stress scale, and Zung-self rating depression questionnaire were introduced to the players immediately after noting the demographic data. Results: The results showed statistically significance with Exercise benefit and barrier scale with P value 0.05 and 36-Item Short Form Survey questionnaire with P value 0.0001 and negative significance between Perceived stress scale with P value of 0.189 and Zung self-rating depression questionnaire with P value 1.291. Conclusion: The study concluded that exercise and general health of the athletes are not getting affected but stress and depression are more prevalent in state level cricketers.
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A preliminary pharmacognostical and physicochemical evaluation of Guduchyadi Vati: A novel herbal formulation for juvenile diabetes p. 64
Vedanshi A Limbachiya, Sagar M Bhinde, C. R. Harisha, Vinay J Shukla
Background: Most of Ayurveda medicines are effective, but they require standardization. Standardization of an herbal formulation is essential to assess the quality of drugs, based on the physicochemical standards and pharmacognostical parameters. Maintaining the quality of any traditional formulation or pharmaceutical product is need of hours to ensure the safety of the patient. A pharmaceutical product that does not meet the required standards can cause a serious threat to public health and safety. Here, an attempt has been made to set preliminary pharmacognostical and pharmaceutical parameters along with high-performance thin-layer chromatography (HPTLC) of one of the novel herbal formulations named Guduchyadi Vati for the treatment of JatajaPrameha (juvenile diabetes). Objective: To evaluate and establish the pharmacognostical and physicochemical parameters of Guduchyadi Vati.Materials and Methods: Preauthenticated raw drugs were procured and prepared at the Pharmacy, Institute of Teaching and Research in Ayurveda (ITRA), Jamnagar. Organoleptic parameters and microscopic analysis of Guduchyadi Vati were done at Pharmacognosy Department, ITRA, Jamnagar. Physicochemical analysis of tablet and HPTLC were done at the Pharmaceutical Laboratory, ITRA, Jamnagar. Results: Microscopic features of Guduchyadi Vati were cross-checked with The Ayurvedic Pharmacopoeia of India standards of individual ingredients, and it was found that all characteristics remain intake. In pharmaceutical parameters, the pH value was 6.5, water-soluble extract was 25.55%, alcohol-soluble extract was 10.32%, ash value was 12.37%, and loss on drying was 0.16%w/w. HPTLC at 254 and 366 nm showed 3 and 16 spots, respectively. Conclusions: This study generated preliminary data on pharmacognostical and physicochemical parameters of Guduchyadi Vati. These fingerprints could be useful for future researchers to the reproduction of this formulation as quality control parameters for Guduchyadi Vati are not available in The Ayurvedic Pharmacopoeia of India or the public domain.
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Vipareeta Vrana Vijnaaneeyam chapter of Sushruta Sutra Sthana: An explorative study p. 70
Kshama Gupta, Prasad Mamidi
Sushruta Samhita, written by Maharshi Sushruta, is one of the oldest Ayurvedic texts dedicated to surgical procedures along with other medical disciplines. Prognostic knowledge is documented in the 28th to 33rd chapters of Sutra Sthana of Sushruta Samhita (SSS). Vipareeta Vrana Vijnaaneeyam (VVV) is the 28th chapter of SSS, and it consists of 21 verses that deal with the prognostic assessment of wounds. The present work is aimed to provide a comprehensive and critical analysis of the contents of VVV chapter with the help of contemporary prognostic literature available on the wounds. Elaborate description is available regarding the prognostic assessment of wounds based on various parameters such as wound odor, color, pain, temperature, shape, size, location, granulation tissue, associated complications, underlying systemic diseases, etc., in VVV chapter. Gas chromatography-ion trap mass spectrometry or e-nose could be used to analyze various wound odors (Vrana Gandha). Red, Yellow & Black classification tool could be incorporated to standardize Vrana Varna (wound color). Various wound microenvironment indices, such as local pH, uric acid, glucose, lactic acid, etc., could be incorporated in standardizing Vrana Rasa (taste-related indices of wound). Wound, wound bed, and periwound temperatures can be used for understanding Vrana Sparsha (touch-related indices of wounds). Smartphones and digital wound measurements could be used to standardize Vrana Aakriti (shape and size of the wound). Most of the conditions described in VVV chapter denote various infectious, ischemic, chronic, and nonhealing ulcers associated with complications and underlying systemic diseases.
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Evidence-based physiotherapy for adhesive capsulitis—Current evidences, challenges, and future directions: Systematic review p. 79
Sandeep B Shinde, Sayalee B Dhane, Pooja P Jain, Sumeeran D Mishra, Vrushali K Kumbhar, Kajal A Thorat, Apurva A Saptale
Slow-onset shoulder pain, localized discomfort close to the deltoid insertion, an inability to sleep on the affected side, limited or restricted glenohumeral elevation and external rotation, and a normal radiological appearance are the primary symptoms of frozen shoulder. Although there is no known cause, variety of interventions have been used primarily due to the prolonged state of pain and disability. This systematic review evaluates and addresses the evidence-based physiotherapy management and challenges respectively for early and complete recovery of adhesive capsulitis patients. Six databases were searched for this systematic review and all were randomized control trials. Each study’s risk of bias was assessed using the Cochrane Collaboration Risk of Bias Tool. This systematic review was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and Patient, Intervention, Comparison, and Outcomes design. Studies from 2000 to 2022 were considered for this systematic review. A total of 568 participants from 14 studies were included in the systematic review. Utilizing outcome measures such as visual analog scale, shoulder pain and disability index, SF-36, shoulder kinematics, and shoulder function questionnaire, the effectiveness of physiotherapy management was evaluated in these 14 research studies. The most frequent results included improvements in shoulder function, pain relief, and range of motion. According to the research cited in the current systematic review, patients with adhesive capsulitis respond very favorably to a combination of mobilization, proprioceptive neuromuscular technique, task-specific training, and modalities.
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Relevance of Ayurvedic concepts and lifestyle in promoting mental health p. 88
Neeru Sharma, Yadevendra Yadav, Khem Chand Sharma
Along with physical condition, mental health serves as an analytical indicator of an individual’s overall well-being. But over time, we develop some habits and behaviors that contribute to mental illness. These behaviors include anxiety and depression. Risk factors for mental illness include a diet low in nutrients, stress, lethargy, bad habits (such as abusing drugs, alcohol, or other substances), and insufficient sleep. The burden of providing healthcare is significantly impacted by mental illness, which affects a large portion of the global population. The primary goal of Ayurveda is the promotion of health through the prevention and treatment of ailments through the concepts of Ayurvedic and Yoga practices, leading to good physical and mental health. Aachara Rasayana, Sadvrutta, Aasana, and Pranayama are beneficial for promoting and preventing mental diseases as well as maintaining good mental health. Ancient sciences like Ayurveda and Yoga mention Daivavyapashraya (mantra chanting), the performance of various Homas (sacrifices), Yuktivyapashrya (use of medications and diet), and Satwavajaya (efforts to control the abnormal mental activity by the practice of Yama, Niyama, Aasana, and Pranayama).
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